BEST way to do multiple wordpress sites with their own database?

I see that Wordpress Multisite is available with this requires the sites to share 1 database. In order for each Wordpress to have its own database, there appears to be 2 ways I've found on this site:

1. Install single site stack each time you want a new wordpress site and specify a different directory and port.
2. Install using chmod a+x bitnami-wordpressmodule.run ./bitnami-wordpress-module.run --wordpress_instance_name wordpress2.

Is there an advantage of using #1 or #2? Whats the difference and is one way better than the other?

Thanks.